منابع مشابه
Analysis of drug dissolution data.
Drug absorption in the human body depends on the dissolution rate of the drug. Suitable dissolution characteristics are important to ensure that the drug will achieve the desired therapeutic effects. To assess the similarity of dissolution rates of several drug lots, we apply a general growth curve model with different covariance structures. The Box-Cox power transformation and the naive log tr...
متن کاملMiniaturization of Drug Solubility and Dissolution Testings
Solubility and drug dissolution are of crucial importance for drug formulations. Poor water-solubility of drug candidates is a major obstacle in drug development, since the oral route is the most patient convenient and cost effective way to deliver drugs. In some cases the low aqueous solubility may limit the bioavailability when the absorption of the drug is dissolution limited. About 40% of t...
متن کاملMicellar Mediated Dissolution of a Hydantion Drug
Dissolution behaviour of both 5, 5-diphenyl hydantoin sodium commonly known as dilantin sodium (DS) and its corresponding marketed capsule dilantin have been studied in aqueous as well as micellar media. Percentage dissolution of both DS and its marketed capsule are found to be low as expected in aqueous medium due to its very low solubility in water. However, their dissolution tendency is foun...
متن کاملPOTASSIUM-ARGON ANALYSIS OF DOMAL SALT BY STEPWISE DISSOLUTION
Potassium-argon analysis by stqwise dissolution provides a way to measure in detail the distribution of argon isotopes and potassium in rock salt. The method can be used for salt that contains only trace amounts of potassium, because the potassium and argon in detrital silicates within the salt are not released during the dissolution. Water may be used as the solvent when relatively large a...
متن کاملKinetDS: An Open Source Software for Dissolution Test Data Analysis
Because drug quality is the focus for pharmaceutical industry and regulatory agencies, the in vitro dissolution test becomes a standard tool for characterization of manufactured products. However, results of the dissolution test must be expressed in mathematical terms; this is realized by fitting various models to the cumulative dissolution curves. The models might be either mechanistic or empi...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 1999
ISSN: 0277-6715,1097-0258
DOI: 10.1002/(sici)1097-0258(19990415)18:7<799::aid-sim81>3.0.co;2-y